Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells

Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells

Colorectal cancer (CRC) cells contain elevated levels of active signal transducer and the activator of transcription (Stat)-3, which exerts proliferative and anti-apoptotic effects. Various molecules produced in the CRC tissue can activate Stat3, but the mechanisms that amplify such an activation ar...

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Bibliographic Details
Main Authors: Claudia Maresca, Giulia Di Maggio, Carmine Stolfi, Federica Laudisi, Marco Colella, Teresa Pacifico, Antonio Di Grazia, Davide Di Fusco, Daniele Congiu, Andrea Martina Guida, Giuseppe Sica, Ivan Monteleone, Giovanni Monteleone
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
colonic neoplasia
Smad
transcription factors
cytokines
Online Access:https://www.mdpi.com/2072-6694/14/20/4993

Internet

https://www.mdpi.com/2072-6694/14/20/4993

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