Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury

Abstract Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired survival pathways contribute to liver injury caused by hepatotoxins. We investigated the role of hepatic autophagy, a cellular survival pathway, in cholestatic liver injury driven by a hepatotoxin. Here w...

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Bibliographic Details
Main Authors: Katherine Byrnes, Niani Tiaye Bailey, Kamal Baral, Arissa Mercer, Spandan Joshi, Nickol Wahby, Tyler Rorison, Gang Liu, Xiao-Ming Yin, Bilon Khambu
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01368-3