The Roles of Endo-Lysosomes in Unconventional Protein Secretion
Protein secretion in general depends on signal sequence (also named leader sequence), a hydrophobic segment located at or close to the NH2-terminus of a secretory or membrane protein. This sequence guides the entry of nascent polypeptides into the lumen or membranes of the endoplasmic reticulum (ER)...
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MDPI AG
2018-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/7/11/198 |
| _version_ | 1797715213937541120 |
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| author | Juhyung Lee Yihong Ye |
| author_facet | Juhyung Lee Yihong Ye |
| author_sort | Juhyung Lee |
| collection | DOAJ |
| description | Protein secretion in general depends on signal sequence (also named leader sequence), a hydrophobic segment located at or close to the NH2-terminus of a secretory or membrane protein. This sequence guides the entry of nascent polypeptides into the lumen or membranes of the endoplasmic reticulum (ER) for folding, assembly, and export. However, evidence accumulated in recent years has suggested the existence of a collection of unconventional protein secretion (UPS) mechanisms that are independent of the canonical vesicular trafficking route between the ER and the plasma membrane (PM). These UPS mechanisms export soluble proteins bearing no signal sequence. The list of UPS cargos is rapidly expanding, along with the implicated biological functions, but molecular mechanisms accountable for the secretion of leaderless proteins are still poorly defined. This review summarizes our current understanding of UPS mechanisms with an emphasis on the emerging role of endo-lysosomes in this process. |
| first_indexed | 2024-03-12T08:03:36Z |
| format | Article |
| id | doaj.art-156d1a8240e64bca910abf0739b29abe |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:03:36Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-156d1a8240e64bca910abf0739b29abe2023-09-02T19:43:31ZengMDPI AGCells2073-44092018-11-0171119810.3390/cells7110198cells7110198The Roles of Endo-Lysosomes in Unconventional Protein SecretionJuhyung Lee0Yihong Ye1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USAProtein secretion in general depends on signal sequence (also named leader sequence), a hydrophobic segment located at or close to the NH2-terminus of a secretory or membrane protein. This sequence guides the entry of nascent polypeptides into the lumen or membranes of the endoplasmic reticulum (ER) for folding, assembly, and export. However, evidence accumulated in recent years has suggested the existence of a collection of unconventional protein secretion (UPS) mechanisms that are independent of the canonical vesicular trafficking route between the ER and the plasma membrane (PM). These UPS mechanisms export soluble proteins bearing no signal sequence. The list of UPS cargos is rapidly expanding, along with the implicated biological functions, but molecular mechanisms accountable for the secretion of leaderless proteins are still poorly defined. This review summarizes our current understanding of UPS mechanisms with an emphasis on the emerging role of endo-lysosomes in this process.https://www.mdpi.com/2073-4409/7/11/198protein translocationmisfolding-associated protein secretion (MAPS)unconventional protein secretionendo-lysosomeintercellular transmission of proteinsprotein quality controlneurodegenerative diseaseschaperone-mediated autophagy |
| spellingShingle | Juhyung Lee Yihong Ye The Roles of Endo-Lysosomes in Unconventional Protein Secretion Cells protein translocation misfolding-associated protein secretion (MAPS) unconventional protein secretion endo-lysosome intercellular transmission of proteins protein quality control neurodegenerative diseases chaperone-mediated autophagy |
| title | The Roles of Endo-Lysosomes in Unconventional Protein Secretion |
| title_full | The Roles of Endo-Lysosomes in Unconventional Protein Secretion |
| title_fullStr | The Roles of Endo-Lysosomes in Unconventional Protein Secretion |
| title_full_unstemmed | The Roles of Endo-Lysosomes in Unconventional Protein Secretion |
| title_short | The Roles of Endo-Lysosomes in Unconventional Protein Secretion |
| title_sort | roles of endo lysosomes in unconventional protein secretion |
| topic | protein translocation misfolding-associated protein secretion (MAPS) unconventional protein secretion endo-lysosome intercellular transmission of proteins protein quality control neurodegenerative diseases chaperone-mediated autophagy |
| url | https://www.mdpi.com/2073-4409/7/11/198 |
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