Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma

Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma

Abstract Background Hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis among all head-and-neck cancers, and treatment options are limited. Tumor microenvironment (TME) analysis can help identify new therapeutic targets and combined treatment strategies. Methods Six primary HPSCC...

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Bibliographic Details
Main Authors: Zhimou Cai, Lin Chen, Siyu Chen, Ruihua Fang, Xiaolin Chen, Wenbin Lei
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cell Communication and Signaling
Subjects:
Single-cell RNA sequencing
Hypopharyngeal squamous cell carcinoma
Tumor microenvironment
Extracellular matrix cancer-associated fibroblast
Precision therapy
Online Access:https://doi.org/10.1186/s12964-023-01312-z

Internet

https://doi.org/10.1186/s12964-023-01312-z

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