Proton Pump Inhibitors Enhance the Antitumor Effect of Chemotherapy for Esophageal Squamous Cell Carcinoma

Proton Pump Inhibitors Enhance the Antitumor Effect of Chemotherapy for Esophageal Squamous Cell Carcinoma

Background: Vacuolar ATPase (V-ATPase) is involved in cancer development. The use of proton pump inhibitors (PPIs) as V-ATPase inhibitors has been reported to enhance the effectiveness of chemotherapy in certain cancers. This study aimed to evaluate the effect of PPIs on chemotherapy for esophageal...

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Bibliographic Details
Main Authors: Shinya Matsumura, Takeshi Ishikawa, Juichiro Yoshida, Ryuichi Morita, Tomoki Sakakida, Yuki Endo, Toshifumi Doi, Ryohei Hirose, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiko Uchiyama, Tomohisa Takagi, Hideyuki Konishi, Kohichiroh Yasui, Yuji Naito, Yoshito Itoh
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
esophageal cancer
vacuolar ATPase (V-ATPase)
proton pump inhibitors (PPIs)
5-Fluorouracil (5-FU)
lansoprazole
esomeprazole
Online Access:https://www.mdpi.com/2072-6694/14/10/2395

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https://www.mdpi.com/2072-6694/14/10/2395

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