Systemic taurine treatment affords functional and morphological neuroprotection of photoreceptors and restores retinal pigment epithelium function in RCS rats

Systemic taurine treatment affords functional and morphological neuroprotection of photoreceptors and restores retinal pigment epithelium function in RCS rats

The aim of our work was to study whether taurine administration has neuroprotective effects in dystrophic Royal College of Surgeons (RCS) rats, suffering retinal degeneration secondary to impaired retinal pigment epithelium phagocytosis caused by a MERTK mutation. Dystrophic RCS-p + female rats (n =...

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Bibliographic Details
Main Authors: Ana Martínez-Vacas, Johnny Di Pierdomenico, Alejandro Gallego-Ortega, Francisco J. Valiente-Soriano, Manuel Vidal-Sanz, Serge Picaud, María Paz Villegas-Pérez, Diego García-Ayuso
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Taurine
Retinal degeneration
RCS
Merkt
RPE
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002786

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722002786

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