Mangostanaxanthone IV Ameliorates Streptozotocin-Induced Neuro-Inflammation, Amyloid Deposition, and Tau Hyperphosphorylation via Modulating PI3K/Akt/GSK-3β Pathway

Mangostanaxanthone IV Ameliorates Streptozotocin-Induced Neuro-Inflammation, Amyloid Deposition, and Tau Hyperphosphorylation via Modulating PI3K/Akt/GSK-3β Pathway

Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is characterized by amyloid deposition and neurofibrillary tangles formation owing to tau protein hyperphosphorylation. Intra-cerebroventricular (ICV) administration of streptozotocin (STZ) has been widely used as a model of sporadi...

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Bibliographic Details
Main Authors: Hossam M. Abdallah, Nesrine S. El Sayed, Alaa Sirwi, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Nora O. Abdel Rasheed
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biology
Subjects:
<i>Garcinia mangostana</i>
mangostanaxanthone IV
xanthones
neuro-inflammation
Alzheimer’s disease
PI3K/Akt/GSK-3β
Online Access:https://www.mdpi.com/2079-7737/10/12/1298

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https://www.mdpi.com/2079-7737/10/12/1298

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