Short-Term Hypothermic Holding of Mouse Immature Testicular Tissue Does Not Alter the Expression of DNA Methyltransferases and Global DNA Methylation Level, Post-Organotypic Culture

Short-Term Hypothermic Holding of Mouse Immature Testicular Tissue Does Not Alter the Expression of DNA Methyltransferases and Global DNA Methylation Level, Post-Organotypic Culture

IntroductionCryopreservation of immature-testicular-tissue (ITT) prior to gonadotoxic treatment, while experimental, is the only recommended option for fertility preservation in prepubertal boys. The handling and manipulation of ITT prior to banking could influence the functionality, genetic and epi...

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Bibliographic Details
Main Authors: Riddhi K. Pandya, Shubhashree Uppangala, Sujith R. Salian, Sanjay Gupta, Guruprasad Kalthur, Stefan Schlatt, Satish Kumar Adiga
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Endocrinology
Subjects:
immature testicular tissue
organotypic culture
hypothermic holding temperature
DNA methylation
epigenetics
DNMT
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.854297/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.854297/full

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