Observing protein dynamics during DNA-lesion bypass by the replisome

Observing protein dynamics during DNA-lesion bypass by the replisome

Faithful DNA replication is essential for all life. A multi-protein complex called the replisome contains all the enzymatic activities required to facilitate DNA replication, including unwinding parental DNA and synthesizing two identical daughter molecules. Faithful DNA replication can be challenge...

Full description

Bibliographic Details
Main Authors: Elise M. Wilkinson, Lisanne M. Spenkelink, Antoine M. van Oijen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
DNA replication
protein dynamics
single-molecule
cryo-EM
cyclobutane pyrimidine dimer
lesion bypass
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.968424/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.968424/full

Similar Items