The effects of amino acid composition of glutamine-rich domains on amyloid formation and fragmentation.

The effects of amino acid composition of glutamine-rich domains on amyloid formation and fragmentation.

Fragmentation of amyloid polymers by the chaperone Hsp104 allows them to propagate as prions in yeast. The factors which determine the frequency of fragmentation are unclear, though it is often presumed to depend on the physical strength of prion polymers. Proteins with long polyglutamine stretches...

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Bibliographic Details
Main Authors: Alexander I Alexandrov, Alla B Polyanskaya, Genrikh V Serpionov, Michael D Ter-Avanesyan, Vitaly V Kushnirov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3468588?pdf=render

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http://europepmc.org/articles/PMC3468588?pdf=render

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