Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monomeric state to a tetramer is essential for necropto...

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Detalles Bibliográficos
Main Authors: Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Formato: Artigo
Idioma:English
Publicado: Nature Portfolio 2018-06-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-018-04714-7

Internet

https://doi.org/10.1038/s41467-018-04714-7

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