IL-15-producing splenic B cells play pathogenic roles in the development of autoimmune hepatitis

IL-15-producing splenic B cells play pathogenic roles in the development of autoimmune hepatitis

Background & Aims: B-cell depletion therapy with an anti-CD20 is an effective treatment strategy for patients with refractory autoimmune hepatitis (AIH). However, the mechanisms underlying B-cell action are unclear. Methods: Herein, we used the adeno-associated virus IL-12 model, in which he...

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Bibliographic Details
Main Authors: Sota Fujimori, Po-Sung Chu, Toshiaki Teratani, Yosuke Harada, Takahiro Suzuki, Takeru Amiya, Nobuhito Taniki, Ryosuke Kasuga, Yohei Mikami, Yuzo Koda, Masataka Ichikawa, Takaya Tabuchi, Rei Morikawa, Karin Yamataka, Fumie Noguchi, Hanako Tsujikawa, Yutaka Kurebayashi, Michiie Sakamoto, Takanori Kanai, Nobuhiro Nakamoto
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:JHEP Reports
Subjects:
Autoimmune hepatitis
B cell
CD8+ T cell
IL-15
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923000885

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http://www.sciencedirect.com/science/article/pii/S2589555923000885

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