Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity

Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity

The potential of Se to alleviate pain associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity was investigated.Swiss mice were intraperitoneally injected with MPTP (20 mg/kg) 4 times with an interval of 2 h in 1 day. Seven days after MPTP injection, the mice (n = 5...

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Bibliographic Details
Main Authors: Patrick Oluwole Abolarin, Abdulrazaq Bidemi Nafiu, Aboyeji Lukuman Oyewole, Abdulbasit Amin, Olalekan Michael Ogundele, Bamidele Victor Owoyele
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:IBRO Neuroscience Reports
Subjects:
Neurotoxicity
Selenium
Motor coordination
Nociceptive threshold
Neuroinflammation
Pain biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242121000476

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http://www.sciencedirect.com/science/article/pii/S2667242121000476

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