Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity
The potential of Se to alleviate pain associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity was investigated.Swiss mice were intraperitoneally injected with MPTP (20 mg/kg) 4 times with an interval of 2 h in 1 day. Seven days after MPTP injection, the mice (n = 5...
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Elsevier
2022-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242121000476 |
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| author | Patrick Oluwole Abolarin Abdulrazaq Bidemi Nafiu Aboyeji Lukuman Oyewole Abdulbasit Amin Olalekan Michael Ogundele Bamidele Victor Owoyele |
| author_facet | Patrick Oluwole Abolarin Abdulrazaq Bidemi Nafiu Aboyeji Lukuman Oyewole Abdulbasit Amin Olalekan Michael Ogundele Bamidele Victor Owoyele |
| author_sort | Patrick Oluwole Abolarin |
| collection | DOAJ |
| description | The potential of Se to alleviate pain associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity was investigated.Swiss mice were intraperitoneally injected with MPTP (20 mg/kg) 4 times with an interval of 2 h in 1 day. Seven days after MPTP injection, the mice (n = 5 mice per group) were randomly assigned to groups: MPTP-, DOPA (50 mg/kg)-, Se4 (0.4 mg/kg)-, Se6 (0.6 mg/kg)-, DOPA+Se4-, and DOPA+Se6-treated groups were compared with controls. MPTP mice were treated for seven days; thereafter, motor-coordination and nociceptive-motor reactions were assessed. Pro-inflammatory cytokines (IL-1β, IL-6 and TNFα), and selected pain biomarkers (substance P (SP), glutamate and β-endorphin) were assessed in the serum and the substantial nigra pars compacta (SNpc).Motor activity was increased slightly by Se (0.6 or 0.4 mg/kg) vs. MPTP (10.48 ± 2.71 or 11.81 ± 1.28 s vs. 3.53 ± 0.06 s respectively) but considerably increased by DOPA (50 mg/kg) vs. MPTP (50.47 ± 3.06 s vs. 3.53 ± 0.06 s respectively). Se and DOPA increased nociceptive threshold but Se alone reduced both serum and SN pro-inflammatory cytokines. Se modulates SP while DOPA modulates SP and glutamate in the SNpc of mice treated with MPTP.Se suppressed pro-inflammatory cytokines and restored the basal pain biomarkers in the SNpc of mice treated with MPTP. Se requires further study as analgesic adjuvant. |
| first_indexed | 2024-12-12T16:28:49Z |
| format | Article |
| id | doaj.art-158d29ff4440452191da5ae905af990f |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-12-12T16:28:49Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-158d29ff4440452191da5ae905af990f2022-12-22T00:18:49ZengElsevierIBRO Neuroscience Reports2667-24212022-06-0112111Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicityPatrick Oluwole Abolarin0Abdulrazaq Bidemi Nafiu1Aboyeji Lukuman Oyewole2Abdulbasit Amin3Olalekan Michael Ogundele4Bamidele Victor Owoyele5Department of Physiology, University of Ilorin, P.M.B 1515, Ilorin, NigeriaDepartment of Human Physiology, Federal University Dutse, Dutse, Jigawa State, NigeriaDepartment of Physiology, University of Ilorin, P.M.B 1515, Ilorin, NigeriaDepartment of Physiology, University of Ilorin, P.M.B 1515, Ilorin, NigeriaDepartment of Comparative Biomedical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA, USADepartment of Physiology, University of Ilorin, P.M.B 1515, Ilorin, Nigeria; Corresponding author.The potential of Se to alleviate pain associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity was investigated.Swiss mice were intraperitoneally injected with MPTP (20 mg/kg) 4 times with an interval of 2 h in 1 day. Seven days after MPTP injection, the mice (n = 5 mice per group) were randomly assigned to groups: MPTP-, DOPA (50 mg/kg)-, Se4 (0.4 mg/kg)-, Se6 (0.6 mg/kg)-, DOPA+Se4-, and DOPA+Se6-treated groups were compared with controls. MPTP mice were treated for seven days; thereafter, motor-coordination and nociceptive-motor reactions were assessed. Pro-inflammatory cytokines (IL-1β, IL-6 and TNFα), and selected pain biomarkers (substance P (SP), glutamate and β-endorphin) were assessed in the serum and the substantial nigra pars compacta (SNpc).Motor activity was increased slightly by Se (0.6 or 0.4 mg/kg) vs. MPTP (10.48 ± 2.71 or 11.81 ± 1.28 s vs. 3.53 ± 0.06 s respectively) but considerably increased by DOPA (50 mg/kg) vs. MPTP (50.47 ± 3.06 s vs. 3.53 ± 0.06 s respectively). Se and DOPA increased nociceptive threshold but Se alone reduced both serum and SN pro-inflammatory cytokines. Se modulates SP while DOPA modulates SP and glutamate in the SNpc of mice treated with MPTP.Se suppressed pro-inflammatory cytokines and restored the basal pain biomarkers in the SNpc of mice treated with MPTP. Se requires further study as analgesic adjuvant.http://www.sciencedirect.com/science/article/pii/S2667242121000476NeurotoxicitySeleniumMotor coordinationNociceptive thresholdNeuroinflammationPain biomarkers |
| spellingShingle | Patrick Oluwole Abolarin Abdulrazaq Bidemi Nafiu Aboyeji Lukuman Oyewole Abdulbasit Amin Olalekan Michael Ogundele Bamidele Victor Owoyele Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity IBRO Neuroscience Reports Neurotoxicity Selenium Motor coordination Nociceptive threshold Neuroinflammation Pain biomarkers |
| title | Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity |
| title_full | Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity |
| title_fullStr | Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity |
| title_full_unstemmed | Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity |
| title_short | Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity |
| title_sort | selenium reduces nociceptive response in acute 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine mptp induced neurotoxicity |
| topic | Neurotoxicity Selenium Motor coordination Nociceptive threshold Neuroinflammation Pain biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2667242121000476 |
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