Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

ABSTRACTSecond-generation COVID-19 vaccines with improved immunogenicity (e.g., breadth, duration) and availability (e.g., lower costs, refrigerator stable) are needed to enhance global coverage. In this work, we formulated a clinical-stage SARS-CoV-2 receptor-binding domain (RBD) virus-like particl...

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Bibliographic Details
Main Authors: Ozan S. Kumru, Sakshi Bajoria, Kawaljit Kaur, John M. Hickey, Greta Van Slyke, Jennifer Doering, Katherine Berman, Charles Richardson, Hans Lien, Harry Kleanthous, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin
Format: Article
Language:English
Published: Taylor & Francis Group 2023-08-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Vaccine
formulation
stability
aluminum-salt
CpG
emulsion
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2023.2264594

Internet

https://www.tandfonline.com/doi/10.1080/21645515.2023.2264594

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