The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

ABSTRACTSphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis. Eukaryotic cells are highly organized with various structures and organelles to facilitate cellular processes and c...

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Bibliographic Details
Main Authors: Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U. Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
sphingofungins
sphingolipid
Aspergillus fumigatus
secondary metabolites
cellular compartments
Online Access:https://journals.asm.org/doi/10.1128/mbio.00195-24

Internet

https://journals.asm.org/doi/10.1128/mbio.00195-24

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