The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin

The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin

The current study investigates the neurotrophic effects of Clostridium botulinum C3 transferase (C3bot) on highly purified, glia-free, GABAergic, and glutamatergic neurons. Incubation with nanomolar concentrations of C3bot promotes dendrite formation as well as dendritic and axonal outgrowth in rat...

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Bibliographic Details
Main Authors: Andrej Adolf, Paul Turko, Astrid Rohrbeck, Ingo Just, Imre Vida, Gudrun Ahnert-Hilger, Markus Höltje
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
C3 transferase
vimentin
GABAergic neurons
glutamatergic neurons
axon outgrowth
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.596072/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.596072/full

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