Influence of Substitutions in the Binding Motif of Proline-Rich Antimicrobial Peptide ARV-1502 on 70S Ribosome Binding and Antimicrobial Activity

Influence of Substitutions in the Binding Motif of Proline-Rich Antimicrobial Peptide ARV-1502 on 70S Ribosome Binding and Antimicrobial Activity

Proline-rich antimicrobial peptides (PrAMPs) are promising candidates to treat bacterial infections. The designer peptide ARV-1502 exhibits strong antimicrobial effects against <i>Enterobacteriaceae</i> both in vitro and in vivo. Since the inhibitory effects of ARV-1502 reported for the...

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Bibliographic Details
Main Authors: Alexandra Brakel, Andor Krizsan, Renke Itzenga, Carl N. Kraus, Laszlo Otvos, Ralf Hoffmann
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
70S ribosome
Chex1-Arg20
dissociation constant (K<sub>d</sub>)
<i>Escherichia coli</i> (<i>E. coli</i>)
inhibition constant (K<sub>i</sub>)
proline-rich antimicrobial peptide (PrAMP) ARV-1502
Online Access:https://www.mdpi.com/1422-0067/23/6/3150

Internet

https://www.mdpi.com/1422-0067/23/6/3150

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