Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK

Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK

Inflammation is a key homeostatic process involved in the body’s response to a multitude of disease states including infection, autoimmune disorders, cancer, and other chronic conditions. When the initiating event is poorly controlled, severe inflammation and globally dysregulated immune responses c...

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Bibliographic Details
Main Authors: Jackline Joy Martín Lasola, Andrea L. Cottingham, Brianna L. Scotland, Nhu Truong, Charles C. Hong, Paul Shapiro, Ryan M. Pearson
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
inflammation
innate immunity
macrophages
Toll-like receptors
TLR
NF-κB
Online Access:https://www.mdpi.com/1999-4923/13/11/1841

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https://www.mdpi.com/1999-4923/13/11/1841

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