Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation

Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation

Abstract Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear tumour staining (MMR protein deficient). Four colonic adenocarcinomas and a gastric adenocarcinoma with associ...

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Bibliographic Details
Main Authors: Aoife J McCarthy, Jose‐Mario Capo‐Chichi, Tara Spence, Sylvie Grenier, Tracy Stockley, Suzanne Kamel‐Reid, Stefano Serra, Peter Sabatini, Runjan Chetty
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:The Journal of Pathology: Clinical Research
Subjects:
adenocarcinoma
colorectal
gastric
mismatch repair proteins
immunohistochemistry
mismatch repair genes
Online Access:https://doi.org/10.1002/cjp2.120

Internet

https://doi.org/10.1002/cjp2.120

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