Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm

Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm

Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic wall, leading to reduced biomechanical support with risk of aortic dissection and rupture. Activation of the renin-angiotensin system, and resultant angiotensin (Ang) II synthesis, is critically involved in t...

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Bibliographic Details
Main Authors: Anshul S. Jadli, Noura N. Ballasy, Karina P. Gomes, Cameron D. A. Mackay, Megan Meechem, Tishani Methsala Wijesuriya, Darrell Belke, Jennifer Thompson, Paul W. M. Fedak, Vaibhav B. Patel
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
thoracic aortic aneurysm (TAA)
angiotensin II
angiotensin 1-7
vascular smooth muscle cells
phenotypic switch
Online Access:https://www.mdpi.com/1422-0067/23/24/15566

Internet

https://www.mdpi.com/1422-0067/23/24/15566

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