Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis.

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis.

Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the identity and function of specific regulators have been diffic...

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Bibliographic Details
Main Authors: Brea K Hampton, Kenneth S Plante, Alan C Whitmore, Colton L Linnertz, Emily A Madden, Kelsey E Noll, Samuel P Boyson, Breantie Parotti, James G Xenakis, Timothy A Bell, Pablo Hock, Ginger D Shaw, Fernando Pardo-Manuel de Villena, Martin T Ferris, Mark T Heise
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010548

Internet

https://doi.org/10.1371/journal.pgen.1010548

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