Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways

Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways

Abstract Background Macrophage M1 polarization plays a pivotal role in inflammatory diseases. Progranulin (PGRN) has potential anti-inflammation action, however, the effect of PGRN on macrophage M1 polarization has been poorly studied. Our study aimed to investigate the effect of PGRN on lipopolysac...

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Bibliographic Details
Main Authors: Lianlian Liu, Hongmei Guo, Aimei Song, Jiahui Huang, Yu Zhang, Shanshan Jin, Shutong Li, Liguo Zhang, Chengzhe Yang, Pishan Yang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Immunology
Subjects:
PGRN
Macrophage polarization
NF-κB
MAPK
Lipopolysaccharide (LPS)
Online Access:http://link.springer.com/article/10.1186/s12865-020-00355-y

Internet

http://link.springer.com/article/10.1186/s12865-020-00355-y

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