Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

<p>Abstract</p> <p>Background</p> <p>Combination immunotherapies can be effective against subcutaneous tumors in mice but the effect against orthotopic malignant disease is less well characterized. In particular, a combination of three agonist antibodies, termed Tri-mAb...

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Bibliographic Details
Main Authors: Sharkey Janelle, Guru Preethi, Darcy Phillip K, Westwood Jennifer A, Pegram Hollie J, Amos Sally M, Smyth Mark J, Kershaw Michael H
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/42