AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo

Intervertebral disc degeneration is the main contributor to low back pain, now the leading cause of disability worldwide. Gene transfer, either in a therapeutic attempt or in basic research to understand the mechanisms of disc degeneration, is a fascinating and promising tool to manipulate the compl...

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Bibliographic Details
Main Authors: Chi Heon Kim, Colleen Oliver, Hamid Dar, Hicham Drissi, Steven M. Presciutti
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-07-01
Series:Genes and Diseases
Subjects:
Adeno-associated virus
Bioluminescence imaging
Cell permeabilization peptide
Intervertebral disc
Lightsheet microscopy
Nucleus pulposus transduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220301665

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http://www.sciencedirect.com/science/article/pii/S2352304220301665

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