Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins

Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins

The development of malignant tumors is caused by a complex combination of genetic mutations and epigenetic alterations, the latter of which are induced by either external environmental factors or signaling disruption following genetic mutations. Some types of cancer demonstrate a significant increas...

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Bibliographic Details
Main Authors: Varvara Maksimova, Valeriia Popova, Anzhelika Prus, Evgeniya Lylova, Olga Usalka, Guzel Sagitova, Ekaterina Zhidkova, Julia Makus, Ekaterina Trapeznikova, Gennady Belitsky, Marianna Yakubovskaya, Kirill Kirsanov
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
CBL0137
epigenetic-targeted therapy
epigenetic modulators
DNA methylation
DNMT3A
BET family proteins
Online Access:https://www.mdpi.com/1422-0067/24/16/12874

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https://www.mdpi.com/1422-0067/24/16/12874

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