Synthesis of N'-(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies

Synthesis of N'-(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies

A wide range of 4-chloro-3,4-dihydroquinazolines hybrid isoniazid derivatives were synthesised efficiently via reaction of 4-chloro-3,4-dihydroquinazolines with isoniazid in the presence of catalytic amount of N,N-diisopropylethylamine (DIPEA) under refluxing methanol. All the title molecules were c...

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Bibliographic Details
Main Authors: Kinjal D. Patel, Rajesh H. Vekariya, Neelam P. Prajapati, Dhaval B. Patel, Hitesh D. Patel, Tauhid Shaikh, Dhanji P. Rajani, Smita Rajani, Naumita S. Shah, Devendrasinh Jhala
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S187853521830056X

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http://www.sciencedirect.com/science/article/pii/S187853521830056X

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