Focused ultrasound-mediated blood–brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma

Focused ultrasound-mediated blood–brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma

Abstract Background Diffuse midline glioma (DMG) is a pediatric tumor with dismal prognosis. Systemic strategies have been unsuccessful and radiotherapy (RT) remains the standard-of-care. A central impediment to treatment is the blood–brain barrier (BBB), which precludes drug delivery to the central...

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Bibliographic Details
Main Authors: Masih Tazhibi, Nicholas McQuillan, Hong-Jian Wei, Matthew Gallitto, Ethan Bendau, Andrea Webster Carrion, Xander Berg, Danae Kokossis, Xu Zhang, Zhiguo Zhang, Chia-Ing Jan, Akiva Mintz, Robyn D. Gartrell, Hasan R. Syed, Adriana Fonseca, Jovana Pavisic, Luca Szalontay, Elisa E. Konofagou, Stergios Zacharoulis, Cheng-Chia Wu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
Focused ultrasound
Radiotherapy
Diffuse midline glioma
Blood–brain barrier opening
Online Access:https://doi.org/10.1186/s12967-024-05096-9

Internet

https://doi.org/10.1186/s12967-024-05096-9

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