FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

Abstract Background Astrocytes play a crucial, yet not fully elucidated role in the selective motor neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities, astrocytes provide important neuronal homeostatic support, however this function is highly compromised in ALS. Th...

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Bibliographic Details
Main Authors: Katarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, Poul Hyttel, Morten Meyer, Lieven Thorrez, Kristine Freude, Ludo Van Den Bosch
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
Astrocyte
Reactivity
Cytokines
Motor unit
Microfluidic
Online Access:https://doi.org/10.1186/s13024-022-00591-3

Internet

https://doi.org/10.1186/s13024-022-00591-3

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