Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo

Abstract Background The immunological composition of the tumor microenvironment has a decisive influence on the biological course of cancer and is therefore of profound clinical relevance. In this study, we analyzed the cooperative effects of integrin β4 (ITGB4) on tumor cells and E-/P-selectin on e...

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Bibliographic Details
Main Authors: Sandra Genduso, Vera Freytag, Daniela Schetler, Lennart Kirchner, Alina Schiecke, Hanna Maar, Daniel Wicklein, Florian Gebauer, Katharina Bröker, Christine Stürken, Karin Milde-Langosch, Leticia Oliveira-Ferrer, Franz L. Ricklefs, Florian Ewald, Gerrit Wolters-Eisfeld, Kristoffer Riecken, Ludmilla Unrau, Linda Krause, Hanibal Bohnenberger, Anne Offermann, Sven Perner, Susanne Sebens, Katrin Lamszus, Linda Diehl, Stefan Linder, Manfred Jücker, Udo Schumacher, Tobias Lange
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Hematology & Oncology
Subjects:
Integrin β4
E-selectin
P-selectin
Myeloid-derived suppressor cell
Anoikis
Tumor-infiltrating leukocyte
Online Access:https://doi.org/10.1186/s13045-023-01413-9

Internet

https://doi.org/10.1186/s13045-023-01413-9

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