Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study
Abstract Background Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-04-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2018 |
| _version_ | 1797387167237931008 |
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| author | Jiaqing Liu Huaqiang Zhou Yaxiong Zhang Yan Huang Wenfeng Fang Yunpeng Yang Shaodong Hong Gang Chen Shen Zhao Xi Chen Zhonghan Zhang Jiayi Shen Wei Xian Jianhua Zhan Yuanyuan Zhao Xue Hou Yuxiang Ma Ting Zhou Hongyun Zhao Li Zhang |
| author_facet | Jiaqing Liu Huaqiang Zhou Yaxiong Zhang Yan Huang Wenfeng Fang Yunpeng Yang Shaodong Hong Gang Chen Shen Zhao Xi Chen Zhonghan Zhang Jiayi Shen Wei Xian Jianhua Zhan Yuanyuan Zhao Xue Hou Yuxiang Ma Ting Zhou Hongyun Zhao Li Zhang |
| author_sort | Jiaqing Liu |
| collection | DOAJ |
| description | Abstract Background Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer. The aim of this study is to investigate the causal effect of DPA on lung cancer with Mendelian randomization (MR) method. Methods With a two‐sample MR approach, we analyzed the summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, 8866 individuals of European ancestry) Consortium and International Lung Cancer Consortium (ILCCO, 11 348 lung cancer cases and 15 861 controls; European ancestry) to assess the possible causal relationship of DPA on the risk of lung cancer. Results Our results indicated that genetically predicted higher DPA level has a positive association with lung cancer, where 1% higher DPA was associated with a 2.01‐fold risk of lung cancer (odds ratio [OR]: 2.01, 95% CI = 1.34‐3.01; P = 7.40 × 10−4). Additionally, lung cancer was not a causal factor for DPA. The results of MR‐Egger regression analysis showed that there was no evidence for the presence of directional horizontal pleiotropy. Conclusions Genetically elevated DPA is positively associated with risk of lung cancer, and more work is needed to investigate the potential mechanisms. |
| first_indexed | 2024-03-08T22:19:56Z |
| format | Article |
| id | doaj.art-15a55c70a670481da1cf06789dab692a |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-08T22:19:56Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-15a55c70a670481da1cf06789dab692a2023-12-18T12:55:50ZengWileyCancer Medicine2045-76342019-04-01841817182510.1002/cam4.2018Docosapentaenoic acid and lung cancer risk: A Mendelian randomization studyJiaqing Liu0Huaqiang Zhou1Yaxiong Zhang2Yan Huang3Wenfeng Fang4Yunpeng Yang5Shaodong Hong6Gang Chen7Shen Zhao8Xi Chen9Zhonghan Zhang10Jiayi Shen11Wei Xian12Jianhua Zhan13Yuanyuan Zhao14Xue Hou15Yuxiang Ma16Ting Zhou17Hongyun Zhao18Li Zhang19Department of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaZhongshan School of Medicine Sun Yat‐sen University Guangzhou ChinaZhongshan School of Medicine Sun Yat‐sen University Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center Guangzhou ChinaAbstract Background Observational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer. The aim of this study is to investigate the causal effect of DPA on lung cancer with Mendelian randomization (MR) method. Methods With a two‐sample MR approach, we analyzed the summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, 8866 individuals of European ancestry) Consortium and International Lung Cancer Consortium (ILCCO, 11 348 lung cancer cases and 15 861 controls; European ancestry) to assess the possible causal relationship of DPA on the risk of lung cancer. Results Our results indicated that genetically predicted higher DPA level has a positive association with lung cancer, where 1% higher DPA was associated with a 2.01‐fold risk of lung cancer (odds ratio [OR]: 2.01, 95% CI = 1.34‐3.01; P = 7.40 × 10−4). Additionally, lung cancer was not a causal factor for DPA. The results of MR‐Egger regression analysis showed that there was no evidence for the presence of directional horizontal pleiotropy. Conclusions Genetically elevated DPA is positively associated with risk of lung cancer, and more work is needed to investigate the potential mechanisms.https://doi.org/10.1002/cam4.2018CausalityDocosapentaenoic acidLung cancerMendelian randomizationPolyunsaturated fatty acid |
| spellingShingle | Jiaqing Liu Huaqiang Zhou Yaxiong Zhang Yan Huang Wenfeng Fang Yunpeng Yang Shaodong Hong Gang Chen Shen Zhao Xi Chen Zhonghan Zhang Jiayi Shen Wei Xian Jianhua Zhan Yuanyuan Zhao Xue Hou Yuxiang Ma Ting Zhou Hongyun Zhao Li Zhang Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study Cancer Medicine Causality Docosapentaenoic acid Lung cancer Mendelian randomization Polyunsaturated fatty acid |
| title | Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study |
| title_full | Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study |
| title_fullStr | Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study |
| title_full_unstemmed | Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study |
| title_short | Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study |
| title_sort | docosapentaenoic acid and lung cancer risk a mendelian randomization study |
| topic | Causality Docosapentaenoic acid Lung cancer Mendelian randomization Polyunsaturated fatty acid |
| url | https://doi.org/10.1002/cam4.2018 |
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