Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.

Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.

Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown. Myeloid-derived suppressor cells (MDSCs) are one of the pre-metastatic niche components that are...

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Detalles Bibliográficos
Autores principales: Junling Zhuang, Jianghong Zhang, Seint T Lwin, James R Edwards, Claire M Edwards, Gregory R Mundy, Xiangli Yang
Formato: Artículo
Lenguaje:English
Publicado: Public Library of Science (PLoS) 2012-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3500251?pdf=render

Internet

http://europepmc.org/articles/PMC3500251?pdf=render

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