Pluripotent stem cell strategies for rebuilding the human brain
Neurodegenerative disorders have been extremely challenging to treat with traditional drug-based approaches and curative therapies are lacking. Given continued progress in stem cell technologies, cell replacement strategies have emerged as concrete and potentially viable therapeutic options. In this...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1017299/full |
| _version_ | 1828307049385033728 |
|---|---|
| author | Francesco Limone Francesco Limone Francesco Limone Francesco Limone Joseph R. Klim Daniel A. Mordes |
| author_facet | Francesco Limone Francesco Limone Francesco Limone Francesco Limone Joseph R. Klim Daniel A. Mordes |
| author_sort | Francesco Limone |
| collection | DOAJ |
| description | Neurodegenerative disorders have been extremely challenging to treat with traditional drug-based approaches and curative therapies are lacking. Given continued progress in stem cell technologies, cell replacement strategies have emerged as concrete and potentially viable therapeutic options. In this review, we cover advances in methods used to differentiate human pluripotent stem cells into several highly specialized types of neurons, including cholinergic, dopaminergic, and motor neurons, and the potential clinical applications of stem cell-derived neurons for common neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ataxia, and amyotrophic lateral sclerosis. Additionally, we summarize cellular differentiation techniques for generating glial cell populations, including oligodendrocytes and microglia, and their conceivable translational roles in supporting neural function. Clinical trials of specific cell replacement therapies in the nervous system are already underway, and several attractive avenues in regenerative medicine warrant further investigation. |
| first_indexed | 2024-04-13T14:53:06Z |
| format | Article |
| id | doaj.art-15a886fcfde549f8850d8da6529505a0 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T14:53:06Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-15a886fcfde549f8850d8da6529505a02022-12-22T02:42:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10172991017299Pluripotent stem cell strategies for rebuilding the human brainFrancesco Limone0Francesco Limone1Francesco Limone2Francesco Limone3Joseph R. Klim4Daniel A. Mordes5Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA, United StatesDepartment of Molecular and Cellular Biology, Harvard Stem Cell Institute, Cambridge, MA, United StatesStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United StatesLeiden University Medical Center, Leiden, NetherlandsFaze Medicines, Cambridge, MA, United StatesInstitute for Neurodegenerative Diseases, Department of Pathology, University of California, San Francisco, San Francisco, CA, United StatesNeurodegenerative disorders have been extremely challenging to treat with traditional drug-based approaches and curative therapies are lacking. Given continued progress in stem cell technologies, cell replacement strategies have emerged as concrete and potentially viable therapeutic options. In this review, we cover advances in methods used to differentiate human pluripotent stem cells into several highly specialized types of neurons, including cholinergic, dopaminergic, and motor neurons, and the potential clinical applications of stem cell-derived neurons for common neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ataxia, and amyotrophic lateral sclerosis. Additionally, we summarize cellular differentiation techniques for generating glial cell populations, including oligodendrocytes and microglia, and their conceivable translational roles in supporting neural function. Clinical trials of specific cell replacement therapies in the nervous system are already underway, and several attractive avenues in regenerative medicine warrant further investigation.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1017299/fullneurodegenerationagingcell replacement therapiesregenerative medicinepluripotent stem cellsdevelopmental neuroscience |
| spellingShingle | Francesco Limone Francesco Limone Francesco Limone Francesco Limone Joseph R. Klim Daniel A. Mordes Pluripotent stem cell strategies for rebuilding the human brain Frontiers in Aging Neuroscience neurodegeneration aging cell replacement therapies regenerative medicine pluripotent stem cells developmental neuroscience |
| title | Pluripotent stem cell strategies for rebuilding the human brain |
| title_full | Pluripotent stem cell strategies for rebuilding the human brain |
| title_fullStr | Pluripotent stem cell strategies for rebuilding the human brain |
| title_full_unstemmed | Pluripotent stem cell strategies for rebuilding the human brain |
| title_short | Pluripotent stem cell strategies for rebuilding the human brain |
| title_sort | pluripotent stem cell strategies for rebuilding the human brain |
| topic | neurodegeneration aging cell replacement therapies regenerative medicine pluripotent stem cells developmental neuroscience |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1017299/full |
| work_keys_str_mv | AT francescolimone pluripotentstemcellstrategiesforrebuildingthehumanbrain AT francescolimone pluripotentstemcellstrategiesforrebuildingthehumanbrain AT francescolimone pluripotentstemcellstrategiesforrebuildingthehumanbrain AT francescolimone pluripotentstemcellstrategiesforrebuildingthehumanbrain AT josephrklim pluripotentstemcellstrategiesforrebuildingthehumanbrain AT danielamordes pluripotentstemcellstrategiesforrebuildingthehumanbrain |