PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury.

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury.

Mitochondrial injury and dysfunction, a significant feature in metabolic syndrome, triggers endothelial cell dysfunction and cell death. Increasing evidence suggests that mitophagy, a process of autophagic turnover of damaged mitochondria, maintains mitochondrial integrity. PINK1 (phosphatase and te...

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Bibliographic Details
Main Authors: Weiwei Wu, Hao Xu, Zemin Wang, Yun Mao, Liangshuai Yuan, Wei Luo, Zhaoqiang Cui, Taixing Cui, Xing Li Wang, Ying H Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4498619?pdf=render

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http://europepmc.org/articles/PMC4498619?pdf=render

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