Individualized therapy: Role of thiopurine S-methyltransferase protein and genetic variants

Thiopurine S-methyltransferase (TPMT: EC 2.1.1.67) is an enzyme that metabolizes immunosuppressive thiopurine medications, used in the treatment of autoimmune diseases, cancer and in transplantation medicine. In some individuals, TPMT enzyme activity is significantly increased or decreased compared...

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Bibliographic Details
Main Authors: Pavlović Sonja, Zukić Branka
Format: Article
Language:English
Published: Society of Medical Biochemists of Serbia, Belgrade 2010-01-01
Series:Journal of Medical Biochemistry
Subjects:
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2010/1452-82581003150P.pdf