PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α

PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α

PGC-1α plays a central role in hepatic gluconeogenesis and has been implicated in the onset of type 2 diabetes. Acetylation is an important posttranslational modification for regulating the transcriptional activity of PGC-1α. Here, we show that PCAF is a pivotal acetyltransferase for acetylating PGC...

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Bibliographic Details
Main Authors: Cheng Sun, Meihong Wang, Xiaoyu Liu, Lan Luo, Kaixuan Li, Shuqiang Zhang, Yongjun Wang, Yumin Yang, Fei Ding, Xiaosong Gu
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009954

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http://www.sciencedirect.com/science/article/pii/S2211124714009954

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