Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing.

Endothelin (ET)-1 is known for the most potent vasoconstrictive peptide that is released mainly from endothelial cells. Several studies have reported ET-1 signaling is involved in the process of wound healing or fibrosis as well as vasodilation. However, little is known about the role of ET-1 in the...

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Main Authors: Katsunari Makino, Masatoshi Jinnin, Jun Aoi, Ikko Kajihara, Takamitsu Makino, Satoshi Fukushima, Keisuke Sakai, Kazuhiko Nakayama, Noriaki Emoto, Masashi Yanagisawa, Hironobu Ihn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4031171?pdf=render