Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels

Abstract The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized transporter systems which regulate transcellular transpor...

Full description

Bibliographic Details
Main Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renée F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao, Peter C. Searson
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Induced pluripotent stem cells
Brain microvascular endothelial cells
Three-dimensional models
Gene expression
Online Access:https://doi.org/10.1186/s12987-022-00377-1

Internet

https://doi.org/10.1186/s12987-022-00377-1

Similar Items