Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia

Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia

Abstract Background Non-obstructive azoospermia (NOA) is the most severe disease in male infertility, but the genetic causes for majority of NOA remain unknown. Methods Two Chinese NOA-affected patients were recruited to identify the genetic causal factor of infertility. Whole-exome sequencing (WES)...

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Bibliographic Details
Main Authors: Yuhua Huang, Ruhui Tian, Junwei Xu, Zhiyong Ji, Yuxiang Zhang, Liangyu Zhao, Chao Yang, Peng Li, Erlei Zhi, Haowei Bai, Sha Han, Jiaqiang Luo, Jingpeng Zhao, Jing Zhang, Zhi Zhou, Zheng Li, Chencheng Yao
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Medical Genomics
Subjects:
CNVs
Meiosis
Azoospermia
Gene mutations
Spermatogenesis
Online Access:https://doi.org/10.1186/s12920-022-01288-8

Internet

https://doi.org/10.1186/s12920-022-01288-8

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