Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts

Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts

Abstract Background Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading‐edge patient‐derived xenografts (PDX) as a means to optimize this th...

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Bibliographic Details
Main Authors: Regina Rab, Annette Ehrhardt, Bhagelu R. Achyut, Disha Joshi, Melissa Gilbert‐Ross, Chunzi Huang, Katharine Floyd, Anton V. Borovjagin, William B. Parker, Eric J. Sorscher, Jeong S. Hong
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Reports
Subjects:
gene transfer
head and neck squamous cell carcinoma
patient‐derived xenografts
purine nucleoside phosphorylase
tropism modified adenovirus
Online Access:https://doi.org/10.1002/cnr2.1708

Internet

https://doi.org/10.1002/cnr2.1708

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