Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response

Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response

Abstract Cellular stress responses including the unfolded protein response (UPR) decide over the fate of an individual cell to ensure survival of the entire organism. During physiologic UPR counter-regulation, protective proteins are upregulated to prevent cell death. A similar strategy induces resi...

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Bibliographic Details
Main Authors: Franziska Gsottberger, Christina Meier, Anna Ammon, Scott Parker, Kerstin Wendland, Rebekka George, Srdjan Petkovic, Lisa Mellenthin, Charlotte Emmerich, Gloria Lutzny-Geier, Markus Metzler, Andreas Mackensen, Vidyalakshmi Chandramohan, Fabian Müller
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06055-w

Internet

https://doi.org/10.1038/s41419-023-06055-w

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