Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

Background: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice and disruption of pyruvate kinase M2 (PKM2) activity is critical herein. Glutathione-S-transferase P (GSTP) has been implicated in asthma pathogenesis and regulates the oxidation state of proteins vi...

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Bibliographic Details
Main Authors: Cheryl van de Wetering, Allison M. Manuel, Mona Sharafi, Reem Aboushousha, Xi Qian, Cuixia Erickson, Maximilian MacPherson, Garrett Chan, Ian M. Adcock, Nazanin ZounematKermani, Florence Schleich, Renaud Louis, Eric Bohrnsen, Angelo D'Alessandro, Emiel F. Wouters, Niki L. Reynaert, Jianing Li, C. Roland Wolf, Colin J. Henderson, Lennart K.A. Lundblad, Matthew E. Poynter, Anne E. Dixon, Charles G. Irvin, Albert van der Vliet, Jos L. van der Velden, Yvonne M. Janssen-Heininger
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Redox Biology
Subjects:
Allergic airways disease
House dust mite
Interleukin-1β
S-glutathionylation
Thymic stromal lymphopoietin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003207

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http://www.sciencedirect.com/science/article/pii/S2213231721003207

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