Immunotherapies in MuSK-positive Myasthenia Gravis; an IgG4 antibody-mediated disease

Immunotherapies in MuSK-positive Myasthenia Gravis; an IgG4 antibody-mediated disease

Muscle-specific kinase (MuSK) Myasthenia Gravis (MG) represents a prototypical antibody-mediated disease characterized by predominantly focal muscle weakness (neck, facial, and bulbar muscles) and fatigability. The pathogenic antibodies mostly belong to the immunoglobulin subclass (Ig)G4, a feature...

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Bibliographic Details
Main Authors: Aigli G. Vakrakou, Eleni Karachaliou, Elisabeth Chroni, Vasiliki Zouvelou, Dimitrios Tzanetakos, Stavroula Salakou, Marianna Papadopoulou, Socrates Tzartos, Konstantinos Voumvourakis, Constantinos Kilidireas, Sotirios Giannopoulos, Georgios Tsivgoulis, John Tzartos
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
Myasthenia Gravis
MuSK
IgG4
anti-CD20
FcRn
CAAR-T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212757/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212757/full

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