Modular co-culture engineering of Yarrowia lipolytica for amorphadiene biosynthesis

Modular co-culture engineering of Yarrowia lipolytica for amorphadiene biosynthesis

Abstract Amorphadiene is the precursor to synthesize the antimalarial drug artemisinin. The production of amorphadiene and artemisinin from metabolically engineered microbes may provide an alternate to plant secondary metabolite extraction. Microbial consortia can offer division of labor, and microb...

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Bibliographic Details
Main Authors: Monireh Marsafari, Fidelis Azi, Shaohua Dou, Peng Xu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Microbial Cell Factories
Subjects:
Y. lipolytica
Co-culture
Amorphadiene
Endoplasmic reticulum
Cellular localization
Online Access:https://doi.org/10.1186/s12934-022-02010-0

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