RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice

RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice

Abstract Background Targeting RNA polymerase-1 (POL1) machinery is a new strategy for suppression of multiple sclerosis (MS) relapse activity. Oral administration of POL1 inhibitor RAM-589.555, which is characterized by high permeability and bioavailability in naïve mice, ameliorates proteolipid pro...

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Bibliographic Details
Main Authors: Rina Zilkha-Falb, Tatyana Rachutin-Zalogin, Lakota Cleaver, Michael Gurevich, Anat Achiron
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Polymerase-1 inhibitor
Experimental autoimmune encephalomyelitis
Microglia
Astrocytes
High-dimensional single-cell mass cytometry
Online Access:http://link.springer.com/article/10.1186/s12974-020-01983-2

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http://link.springer.com/article/10.1186/s12974-020-01983-2

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