Mitochondria as biological targets for stem cell and organismal senescence
Organismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been de...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933523000043 |
| _version_ | 1827920693042348032 |
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| author | Ana Branco Inês Moniz João Ramalho-Santos |
| author_facet | Ana Branco Inês Moniz João Ramalho-Santos |
| author_sort | Ana Branco |
| collection | DOAJ |
| description | Organismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been described as a potential interventional target to hinder the loss of stem cell robustness, and subsequently, decrease tissue turnover decline and age-associated pathologies. In this review, we focused our analysis on the most recent literature on mitochondria and stem cell aging and discuss the potential benefits of targeting mitochondria in preventing stem cell dysfunction and thus influencing aging. |
| first_indexed | 2024-03-13T04:14:14Z |
| format | Article |
| id | doaj.art-15be81e1bb4d4e4399e6a267de58c1aa |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-03-13T04:14:14Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-15be81e1bb4d4e4399e6a267de58c1aa2023-06-21T06:50:52ZengElsevierEuropean Journal of Cell Biology0171-93352023-06-011022151289Mitochondria as biological targets for stem cell and organismal senescenceAna Branco0Inês Moniz1João Ramalho-Santos2CNC—Centre for Neuroscience and Cell Biology, CIBB—Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Azinhaga de Santa Comba, Polo 3, 3000-548 Coimbra, PortugalCNC—Centre for Neuroscience and Cell Biology, CIBB—Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Azinhaga de Santa Comba, Polo 3, 3000-548 Coimbra, Portugal; Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Casa Costa Alemão, Polo 2, 3030-789 Coimbra, PortugalCNC—Centre for Neuroscience and Cell Biology, CIBB—Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Azinhaga de Santa Comba, Polo 3, 3000-548 Coimbra, Portugal; Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal; Corresponding author at: Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.Organismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been described as a potential interventional target to hinder the loss of stem cell robustness, and subsequently, decrease tissue turnover decline and age-associated pathologies. In this review, we focused our analysis on the most recent literature on mitochondria and stem cell aging and discuss the potential benefits of targeting mitochondria in preventing stem cell dysfunction and thus influencing aging.http://www.sciencedirect.com/science/article/pii/S0171933523000043Mesenchymal stem cellAgingMitochondria |
| spellingShingle | Ana Branco Inês Moniz João Ramalho-Santos Mitochondria as biological targets for stem cell and organismal senescence European Journal of Cell Biology Mesenchymal stem cell Aging Mitochondria |
| title | Mitochondria as biological targets for stem cell and organismal senescence |
| title_full | Mitochondria as biological targets for stem cell and organismal senescence |
| title_fullStr | Mitochondria as biological targets for stem cell and organismal senescence |
| title_full_unstemmed | Mitochondria as biological targets for stem cell and organismal senescence |
| title_short | Mitochondria as biological targets for stem cell and organismal senescence |
| title_sort | mitochondria as biological targets for stem cell and organismal senescence |
| topic | Mesenchymal stem cell Aging Mitochondria |
| url | http://www.sciencedirect.com/science/article/pii/S0171933523000043 |
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