Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

Whether mRNA SARS-CoV-2 vaccines promote T cells within the nasal mucosa of vaccine recipients is not known. Here the authors show that after mRNA SARS-CoV-2 vaccination, antigen specific T cells can be measured in the nasal mucosa and that these T cells may be localised to respond to a subsequent v...

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Bibliographic Details
Main Authors: Aloysious Ssemaganda, Huong Mai Nguyen, Faisal Nuhu, Naima Jahan, Catherine M. Card, Sandra Kiazyk, Giulia Severini, Yoav Keynan, Ruey-Chyi Su, Hezhao Ji, Bernard Abrenica, Paul J. McLaren, T. Blake Ball, Jared Bullard, Paul Van Caeseele, Derek Stein, Lyle R. McKinnon
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30913-4

Internet

https://doi.org/10.1038/s41467-022-30913-4

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