Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms.

Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms.

Parathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R), which is highly expressed in osteocytes. To determine the cellular and molecular mechanisms responsible, we examined the effects of PTH on osteob...

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Bibliographic Details
Main Authors: Matthew Prideaux, Sarah L Dallas, Ning Zhao, Erica D Johnsrud, Patricia A Veno, Dayong Guo, Yuji Mishina, Stephen E Harris, Lynda F Bonewald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4420268?pdf=render

Internet

http://europepmc.org/articles/PMC4420268?pdf=render

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