DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION
The effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed withorotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control. The livermalondialdehyde (MDA) content increased by 10%, but the gluthatio...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2011-11-01
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| Series: | Makara Seri Sains |
| Subjects: | |
| Online Access: | http://journal.ui.ac.id/science/article/viewFile/1057/970 |
| _version_ | 1811301491102711808 |
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| author | Yohanes Buang |
| author_facet | Yohanes Buang |
| author_sort | Yohanes Buang |
| collection | DOAJ |
| description | The effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed withorotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control. The livermalondialdehyde (MDA) content increased by 10%, but the gluthation peroxidase (GSH-Px) activity decreased by 50%.The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities increased by 25% and 30%,respectively. Therefore, the decreased GSH-Px activity was associated with the promotions of AST, ALT, and the liverMDA levels. In conclusion: dietary orotic acid promotes lipid peroxidation but reduces the rate of the antioxidantenzyme. Therefore, dietary food fortified with orotic acid attenuates the liver function. |
| first_indexed | 2024-04-13T07:09:46Z |
| format | Article |
| id | doaj.art-15c66b362a534583917b93e7ade2db85 |
| institution | Directory Open Access Journal |
| issn | 1693-6671 |
| language | English |
| last_indexed | 2024-04-13T07:09:46Z |
| publishDate | 2011-11-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Seri Sains |
| spelling | doaj.art-15c66b362a534583917b93e7ade2db852022-12-22T02:56:54ZengUniversitas IndonesiaMakara Seri Sains1693-66712011-11-01152101105DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTIONYohanes BuangThe effects of dietary food fortified with orotic acid (1.0%) on liver function were studied in rats. The rats fed withorotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control. The livermalondialdehyde (MDA) content increased by 10%, but the gluthation peroxidase (GSH-Px) activity decreased by 50%.The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities increased by 25% and 30%,respectively. Therefore, the decreased GSH-Px activity was associated with the promotions of AST, ALT, and the liverMDA levels. In conclusion: dietary orotic acid promotes lipid peroxidation but reduces the rate of the antioxidantenzyme. Therefore, dietary food fortified with orotic acid attenuates the liver function.http://journal.ui.ac.id/science/article/viewFile/1057/970animal modelliver functionsteatohepatitis |
| spellingShingle | Yohanes Buang DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION Makara Seri Sains animal model liver function steatohepatitis |
| title | DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION |
| title_full | DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION |
| title_fullStr | DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION |
| title_full_unstemmed | DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION |
| title_short | DIETARY FOOD FORTIFIED WITH OROTIC ACID AND LIVER FUNCTION |
| title_sort | dietary food fortified with orotic acid and liver function |
| topic | animal model liver function steatohepatitis |
| url | http://journal.ui.ac.id/science/article/viewFile/1057/970 |
| work_keys_str_mv | AT yohanesbuang dietaryfoodfortifiedwithoroticacidandliverfunction |