Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathway

Huntington's disease (HD) is a heritable, fatal neurodegenerative disorder caused by a mutation in the Huntingtin gene. It is characterized by chorea, as well as cognitive and psychiatric symptoms. Histopathologically, there is a massive loss of striatal projection neurons and less but signific...

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Bibliographic Details
Main Authors: Joshua Barry, Minh T.N. Bui, Michael S. Levine, Carlos Cepeda
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121003235